Squamous cells make up the outer layer of the cervix and vagina (picture 1). Atypical squamous cells (ASC) is the name given to squamous cells on a Pap smear or cervical cytology that do not have a normal appearance but are not clearly precancerous. Low grade squamous intraepithelial lesions (LSIL, also called low grade cervical intraepithelial neoplasia) refers to cells that appear slightly abnormal.
Women who have ASC or LSIL require further testing because some women with these findings have a precancerous lesion of the cervix.
This topic review discusses the management of women with ASC and LSIL. The management of women with high grade squamous intraepithelial lesions (HSIL) and atypical glandular cells (AGC) are discussed in a separate topic review.