High grade cervical squamous intraepithelial lesion (HSIL, also called high grade cervical intraepithelial neoplasia) is the name given to moderately to severely abnormal-appearing cells on a Pap smear (also called a cervical cytology test). Any woman with HSIL requires further evaluation to determine if cancerous cells are present. While only about 2 percent of women with HSIL have invasive cancer, up to 20 percent of women with HSIL will eventually develop cancer if the abnormality is not treated.
Atypical glandular cells (AGC) is the name given to abnormal appearing glandular cells on a cervical cytology test. Glandular cells line the opening in the cervix (picture 1). AGC is a relatively uncommon result, although it always requires further evaluation. AGC can be caused by benign conditions, such as cervical polyps, or more serious conditions, such as cancer of the cervix, uterine lining (endometrium), ovary, or fallopian tube.